Nancy Guthrie Missing Case DNA Test on Glove Shows No Match in National Database

Police tested DNA from a glove found 2 miles from Nancy Guthrie's house. The results did not match any of the millions of people in the federal database.
By Newsroom | Crime, Arizona |

The search for Nancy Guthrie, the 84-year-old mother of news anchor Savannah Guthrie, continues with a key piece of evidence yielding no immediate leads. A glove found near Guthrie's home, believed to potentially belong to an abductor, has been tested for DNA. However, preliminary results indicate that the DNA profile from the glove does not match any entries within the federal CODIS (Combined DNA Index System) database. This development means that the DNA on the glove, so far, has not helped identify any potential suspects in the ongoing investigation.

No DNA matches on glove found in Nancy Guthrie case, police say - 1

Investigation Timeline and Key Actors

Nancy Guthrie was reported missing on February 1st from her home in Pima County, Arizona. Investigators believe she was taken against her will. The Pima County Sheriff's Department, along with the FBI, are leading the investigation.

No DNA matches on glove found in Nancy Guthrie case, police say - 2

  • February 1st: Nancy Guthrie is last seen at her home.

  • February 2nd: Members of her church notice her absence and notify her family.

  • Early February: Authorities begin their investigation, treating the disappearance as an abduction.

  • February 10th: Federal authorities release images and video from Guthrie's doorbell camera.

  • February 15th/16th: A glove is discovered approximately two miles from Guthrie's home. Preliminary DNA testing is conducted.

  • February 17th (Tuesday): Sheriff Chris Nanos announces that DNA from the glove has produced no matches in the national database.

Evidence and Findings

The primary focus of recent reports is the DNA analysis of a glove found near Nancy Guthrie's home.

Read More: Prince Andrew Arrested in UK on February 19, 2026, for Misconduct

No DNA matches on glove found in Nancy Guthrie case, police say - 3

  • The Glove: The glove was found about two miles from Guthrie's residence. It bears resemblance to one seen on a suspect in doorbell camera footage from the night of her disappearance.

  • DNA Results: DNA extracted from the glove was submitted to the CODIS database. The Pima County Sheriff's Department confirmed that there were "no DNA hits" or matches within this national system.

  • Additional DNA: DNA evidence found at Guthrie's home is also being analyzed. This DNA has also not matched any records in the federal system. Blood, later confirmed to be Guthrie's, was found on her front porch.

  • Pacemaker Data: Guthrie's pacemaker app indicated a disconnection from her phone at 2:28 a.m. on February 1st.

  • Suspects: Nancy Guthrie's family members, including her children and their spouses, have been thoroughly investigated and are not considered suspects in her disappearance. All individuals detained for questioning have been released.

Investigative Steps and Analysis

The lack of a DNA match from the glove presents a challenge for investigators, prompting them to consider alternative avenues.

No DNA matches on glove found in Nancy Guthrie case, police say - 4

The CODIS Database and Its Limitations

  • The Combined DNA Index System (CODIS) is a national database that contains DNA profiles from convicted offenders, arrestees (in some jurisdictions), and forensic samples from crime scenes.

  • A "no match" result from CODIS means the DNA on the glove does not belong to anyone currently in that specific database. This does not rule out the possibility that the DNA belongs to an unknown individual or someone not yet in the system.

Search of Genealogy Databases

  • As a next step, investigators plan to search commercial genealogy databases using the DNA profile from the glove.

  • This method, often referred to as "familial DNA searching," can help identify potential relatives of an unknown suspect, which could then lead to identifying the individual. This process is more complex and requires careful consideration of privacy.

Exclusion of Family Members

  • Investigators have stated that Nancy Guthrie's immediate family has been cleared as suspects. This suggests a thorough review of their potential involvement and alibis has been completed.

  • The presence of blood on the porch, combined with the belief that she was taken against her will, points towards an external party being responsible for her disappearance.

Other Evidence Being Analyzed

  • DNA found at Guthrie's home, separate from the glove, is still undergoing analysis.

  • The pacemaker data, indicating a potential time of disturbance or movement, is also a critical piece of information being integrated into the timeline.

Expert Insights

While no direct expert quotes are provided in the source material regarding the DNA findings, the investigative steps taken, such as the use of CODIS and the planned search of genealogy databases, are standard procedures in modern forensic investigations. The Sheriff's Department's methodical approach underscores the complexity of the case.

Conclusion and Implications

The absence of a DNA match from the glove in the CODIS database is a significant, albeit inconclusive, finding in the Nancy Guthrie case. It suggests the individual whose DNA was on the glove is either not in the national criminal DNA database or is someone not yet identified through forensic means.

  • Next Steps: The investigation will likely proceed with the planned analysis of commercial genealogy databases and continue to explore other leads and evidence collected from Guthrie's home.

  • Unidentified Perpetrator: The current results imply that the perpetrator, if their DNA was indeed on the glove, is not a known offender within the federal system.

  • Ongoing Search: The family and law enforcement remain hopeful for Nancy Guthrie's safe return, and the public has been urged to provide any relevant information.

Sources Used:

Frequently Asked Questions

Q: Why did the DNA test on the glove found in the Nancy Guthrie case fail to find a suspect?
The DNA from the glove was checked against the national CODIS database on Tuesday, February 17th. It did not match any known criminals or people already in the system. This means the person who wore the glove is not currently in the federal records.
Q: When was 84-year-old Nancy Guthrie last seen before she went missing in Arizona?
Nancy Guthrie was last seen at her home in Pima County on February 1st. Her family and church members noticed she was gone the next day. Police believe she was taken from her home against her will.
Q: What did the pacemaker app data tell police about Nancy Guthrie's disappearance?
Data from Nancy Guthrie's pacemaker showed it stopped talking to her phone at 2:28 a.m. on February 1st. This helps police know exactly when something happened to her. They are using this time to check cameras and other evidence.
Q: Are the children or family of Nancy Guthrie suspects in her missing person investigation?
No, the Pima County Sheriff's Department said that all of Nancy Guthrie's family members have been cleared. This includes her children and their husbands or wives. Police are now looking for a person outside of the family.
Q: What is the next step for the Pima County Sheriff to find the person who left DNA on the glove?
Since the national database had no match, police will now use genealogy websites to find the person's relatives. This search can help them find the person by looking at their family tree. They are also testing other DNA found at her house.