Actor Eric Dane has died at the age of 53. His passing follows a diagnosis of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. Dane announced his ALS diagnosis in April 2025, and his representatives confirmed his death, stating that the disease had progressed significantly.
Context and Timeline
Eric Dane, a familiar face in television, gained widespread recognition for his role as Dr. Mark Sloan, nicknamed "McSteamy," in the ABC medical drama "Grey's Anatomy," a role he held for eight seasons starting in 2006. His career also included significant parts in the HBO series "Euphoria" and films such as "X-Men: Last Stand" (2006) and "Burlesque" (2010).
April 2025: Eric Dane publicly announced his diagnosis with amyotrophic lateral sclerosis (ALS).
June 2025: Dane spoke about his declining health, noting the loss of function in his right side and the rapid loss of voluntary movement in his left arm, telling ABC's Diane Sawyer, "I feel like maybe a couple, few more months and I won't have my left hand either."
September [Year Not Specified, but likely 2025]: The ALS Network recognized Dane's advocacy by naming him "advocate of the year."
February 19, 2026: Multiple news outlets reported Dane's death at the age of 53. His representatives confirmed his passing due to ALS.
Evidence of Death and Cause
Official statements from Dane's representatives, as reported by various news agencies, confirm his death. The cause cited is amyotrophic lateral sclerosis (ALS).

"His representatives said Dane died from amyotrophic lateral sclerosis, known also as Lou Gehrig’s disease, less than a year after he announced his diagnosis." - AP News
"Eric Dane, 'Grey's Anatomy' star diagnosed with ALS, dies at 53. Eric Dane, the actor best known for his role as Dr. Mark Sloan on the hit medical series "Grey's Anatomy," has died at the age of 53, his family announced Thursday." - CBS News
"Eric Dane, the handsome and hunky actor who steamed up primetime TV on “Grey’s Anatomy” at the height of the show’s popularity, has died, according to his publicist." - CNN
Medical Condition: ALS
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord.
It destroys the nerve cells required for voluntary movement, impacting the ability to walk, talk, speak, and breathe.
According to the Mayo Clinic, ALS is a disease that impacts the nervous system and affects the brain and spinal cord.
Typically, most patients die within three to five years of their diagnosis.
Career and Public Life
Eric Dane's acting career spanned several decades, with notable roles that endeared him to a wide audience.
Key Roles
Dr. Mark Sloan ("McSteamy"): A defining role in "Grey's Anatomy" from 2006.
"Euphoria": Played the father of Nate Jacobs.
Film Appearances: Including "X-Men: Last Stand" (2006) and "Burlesque" (2010).
ALS Advocacy
Following his diagnosis, Dane became an advocate for ALS awareness.
He spoke at a news conference in Washington regarding health insurance prior authorization.
The ALS Network honored him with their advocate of the year award for his efforts.
In his role on NBC's "Brilliant Minds," he portrayed a firefighter diagnosed with ALS, a role that resonated with his personal experience.
Personal Reflections and Fan Impact
Dane's public persona and his battle with ALS were met with support from fans and colleagues.
Read More: Actor Eric Dane Dies on February 19 2026 at Age 53 from ALS Disease

"Eric adored his fans and is forever grateful for the outpouring of love and support he’s received. He will be deeply missed, and lovingly remembered always." - CNN, USA Today
He shared personal details about his health struggles, including the physical limitations caused by ALS.
"My left side is functioning; my right side has completely stopped working," Dane told ABC's Diane Sawyer in June 2025, adding that he was rapidly losing voluntary function in his left arm. - ABC News
Expert Insights
ALS is a complex and devastating disease, and its impact is often profound.

ALS gradually destroys the nerve cells and connections needed to walk, talk, speak and breathe. Most patients die within three to five years of a diagnosis. - AP News
The rapid progression of the disease, as described by Dane and reported by his representatives, aligns with typical presentations of ALS.
Conclusion and Implications
Eric Dane's death at 53 marks the end of a notable acting career and highlights the aggressive nature of ALS. His public announcement and subsequent advocacy brought greater attention to the disease, potentially informing and inspiring others facing similar health challenges. The outpouring of gratitude from fans underscores his impact on popular culture. His contributions to both entertainment and ALS awareness remain a lasting legacy.
Sources
ABC News: https://abcnews.go.com/GMA/Culture/greys-anatomy-star-eric-dane-dies-53-after/story?id=124500080
Context: This report details Dane's statements about his declining health and his role in "Grey's Anatomy."
CBS News: https://www.cbsnews.com/news/eric-dane-greys-anatomy-euphoria-dies-at-53/
Context: This report confirms Dane's death and lists his other notable acting credits, including "Euphoria" and "X-Men: Last Stand," while providing a general description of ALS.
AP News: https://apnews.com/article/eric-dane-dead-a2eaf3916d047c038ac1121af9a99f17
Context: This report emphasizes Dane's advocacy work for ALS awareness, including his "advocate of the year" award, and describes the progressive nature of ALS.
CNN: https://edition.cnn.com/2026/02/19/entertainment/eric-dane-death
Context: This report confirms Dane's death, highlights his "handsome and hunky" image, and includes a statement about his gratitude to fans.
USA Today: https://www.usatoday.com/story/entertainment/celebrities/2026/02/19/eric-dane-dead-als/88769523007/
Context: This report mentions Dane's loss of use of his right arm and his portrayal of an ALS-diagnosed character in "Brilliant Minds."
Collider: https://collider.com/eric-dane-greys-anatomy-star-dead-at-53/
Context: This report discusses Dane's legacy, his role in the ALS community, and his appeal across different fan generations due to roles in "Euphoria" and "Grey's Anatomy."
Fox News: https://www.foxnews.com/entertainment/greys-anatomy-star-eric-dane-dead-53
Context: This report notes Dane's courageous battle with ALS and mentions his past struggles with depression, though it doesn't directly link it to his death.
The Independent: https://www.independent.co.uk/arts-entertainment/tv/news/eric-dane-death-als-greys-anatomy-euphoria-b2838183.html
Context: This article was flagged for low priority due to insufficient summary data.