Patrick Dempsey, known for his role alongside Eric Dane in Grey's Anatomy, has shared his sorrow and admiration for his late co-star. Dane passed away recently, having publicly shared his diagnosis of Amyotrophic Lateral Sclerosis (ALS) about a year prior. Dempsey spoke about their time working together, emphasizing Dane's humor and intelligence, and reflecting on the profound loss felt by those who knew him.

Background
Eric Dane, who portrayed Dr. Mark Sloan on Grey's Anatomy for many years, died on a recent Thursday at the age of 53. His family confirmed his passing, stating he had been in a "courageous battle with ALS." Dane had shared his diagnosis of this motor neurone disease approximately ten months before his death. Alongside his Grey's Anatomy role, Dane also appeared in Charmed and Euphoria. Patrick Dempsey, who played Dr. Derek Shepherd, or "McDreamy," alongside Dane's "McSteamy," shared his memories and grief in interviews following the news.
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Tributes to Eric Dane
Tributes have emerged from colleagues and fans, with Patrick Dempsey offering a particularly heartfelt remembrance. Dempsey's statements, primarily made during an interview on The Chris Evans Breakfast Show on Virgin Radio UK, highlight several key aspects of Dane's character and their professional relationship.

Remembering Dane's Personality
Humor and Joy: Multiple sources emphasize Eric Dane's strong sense of humor. Dempsey described him as "wickedly intelligent" and "the funniest man," noting that Dane brought "so much fun" to the set of Grey's Anatomy.
"I want to remember him in that spirit because any time he was on set, he brought so much fun to it." (Article 3)
"He had a great sense of humour. He loved catching people off guard. He loved the absurdity of things." (Article 2)
Intelligence and Impact: Beyond his humor, Dane was recognized for his sharp intellect. Dempsey remarked on Dane's "wickedly intelligent" nature and the joy he brought to others.
"The real loss is for us who don’t have them anymore." (Article 1)
The Final Days
Dempsey provided a somber glimpse into Dane's final days, describing him as having been "bedridden" and experiencing difficulties with speech and swallowing. Despite these hardships, Dempsey spoke of Dane's bravery and his desire to remember him before the illness took its toll.

Patrick Dempsey revealed Dane had been bedridden and was losing his ability to speak and swallow in his final days. (Article 6)
Dempsey also expressed sadness for Dane's children. (Article 2, Article 6)
Professional Relationship
Dempsey and Dane worked closely together for approximately five years on Grey's Anatomy, portraying the popular "McDreamy" and "McSteamy" characters. Their on-screen dynamic was a significant element of the show's success.
Dempsey recounted his initial impression of Dane's on-screen introduction: "First scene was him, you know, in all his glory, coming out of the bathroom with the towel on, looking amazing, making you feel completely out of shape and insignificant." (Article 5)
Dempsey also mentioned that he and Dane had discussed a potential Grey's Anatomy reunion amidst Dane's ALS battle. (Article 7)
Expert Analysis
The public discussion surrounding Eric Dane's passing and Patrick Dempsey's tributes highlight the deep impact actors can have on their colleagues and the audience. The emphasis on Dane's humor and intelligence, even in the face of a severe illness, offers a perspective on maintaining dignity and spirit during difficult times.
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The reporting notes Dane's bravery and his role as an advocate for ALS awareness following his diagnosis. (Article 4)
Conclusion
Eric Dane's passing marks the end of a notable career in television and film. Patrick Dempsey's tributes serve as a testament to the personal connections forged within the entertainment industry. The accounts focus on Dane's positive personal attributes—his humor, intelligence, and the joy he brought—as well as the courage he displayed in his final year. The statements suggest a profound sense of loss among those who knew him and worked alongside him, underscoring the personal impact of his absence.
Sources
Huffington Post UK: Published 6 hours ago. Provides Dempsey's reflections on Dane's humor, intelligence, and the personal loss.
The Standard: Published 4 hours ago. Details Dempsey's account of Dane's personality traits and his sadness for Dane's children.
Metro: Published 16 hours ago. Reports on Dane's death, his ALS diagnosis timeline, and Dempsey's tribute focusing on Dane's comedic presence.
Rolling Stone: Published 16 hours ago. Focuses on Dempsey speaking with Dane days before his death and the desire to remember him positively.
Q102: Published 16 hours ago. Features Dempsey's tribute, noting Dane's humor and initial on-screen impact.
Socialite Life: Published 16 hours ago. Details Dempsey's account of Dane's final days and his expression of sadness.
CinemaBlend: Published Jan 30, 2026. Mentions Dempsey's commendation of Dane and their discussion about a Grey's Anatomy reunion.